|“||Yes, perhaps I should take up carpentry. I could build us all coffins.||”|
— Rachel to Susan
Siobhan wants vengeance for her mother. Cosima and Susan Duncan try to come together to try to finally find the cure. Neolution continues with their threats causing Alison to be terrified, and Siobhan to question Alison's loyalty to her sestras.
- Tatiana Maslany as Sarah Manning, Cosima Niehaus, Alison Hendrix, Helena, Rachel Duncan, Krystal Goderitch, and M.K.
- Jordan Gavaris as Felix Dawkins
- Kevin Hanchard as Arthur Bell
- Ari Millen as Ira
- Josh Vokey as Scott Smith
- Kristian Bruun as Donnie Hendrix
- Maria Doyle Kennedy as Scott Smith
- Rosemary Dunsmore as Susan Duncan
- Skyler Wexler as Kira Manning
- Jessalyn Wanlim as Evie Cho
- Gord Rand as Detective Martin Duko
- Lauren Hammersley as Adele
- Cynthia Galant as Charlotte Bowles
- Terra Hazelton as Sarah Stubbs
- Ryan Blakely as Reverend Mike
- Calwyn Shurgold as Hell Wizard
- Brendan Beiser as Friendly Guy
- Noah Danby as Threatening Neo
- Carlos Fortin as Detention Guard #1
- Chavis Brown as Detention Guard #2
- Barbara Johnston as Backup Singer #1
- Anika Johnson as Backup Singer #2
- Géza Kovács as The Messenger
Cosima: Yo, Rachel.
- Rachel: (in a mocking voice) Yo.